Counteracting toxic protein aggregation
نویسندگان
چکیده
منابع مشابه
Toxic tau aggregation in AD.
The pathological hallmarks of Alzheimer’s disease (AD) are extracellular β-amyloid deposition and intracellular tau inclusions. While β-amyloid deposition does not correlate with clinical progression of AD, the diffusion of neurofibrillary tangles (NFTs) from the entorhinal cortex to the neocortex, followed by neuronal and synapse loss, matches well with the clinical progression of AD symptomat...
متن کاملBeta-catenin Forms Protein Aggregation at High Concentrations in HEK293TCells
Background: The canonical Wnt signal transduction (or the Wnt/β-catenin pathway) plays a crucial role in the development of animals and in carcinogenesis. Beta-catenin is the central component of this signaling pathway. The activation of Wnt/β-catenin signaling results in the cytoplasmic and nuclear accumulation of β-catenin. In the nucleus, β-catenin interacts with the TCF/LEF transcription fa...
متن کاملProtein aggregation
As a rule amyloid fibrils appear as unbranched, long rodor ribbon-like structures with the typical diameter of about 10 nm and the length reaching up to 1μm and more. Amyloid fibrils are exceptionally stable against chemical denaturants or temperature. Experiments show that they can withstand up to 8M urea or the temperatures as high as 100 °C (prion fibrils). From a macroscopic viewpoint, form...
متن کاملAcrolein, the toxic endogenous aldehyde, induces neurofilament-L aggregation.
Acrolein is a highly reactive by product of lipid peroxidation and individuals with neurodegenerative disorders have been shown to contain elevated concentrations of this molecule in the brain. In the present study, we examined the pattern of neurofilament-L (NF-L) modification elicited by acrolein. When NF-L was incubated with acrolein, protein aggregation occurred in a acrolein concentration-...
متن کامل1202 Mouse - Toxic Protein Components
Gel electrophoresis has been used in studying protein components in crude cell fractions for metabolic studies (1, 2) and in determining the pur i ty of isolated proteins (3). While determining the feasibility of this method to locate the murine toxin in crude cell fractions of PasteureUa pestis, we observed that toxin activi ty was associated with more than one protein component of the patiall...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2017
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm.2017.24